Endocrine Abstracts

Background: Mounting evidence points to an association between increased glucocorticoid (GC) action and weight gain. However, the response to GCs is not only determined by GC serum concentrations, but also by individual differences in tissue-specific sensitivity, influenced by genetic and acquired (e.g. disease-related) factors. The extent to which differences in GC sensitivity may influence development of (abdominal) obesity, or vice versa, is poorly understood. In this study...

BackgroundLong-term glucocorticoids, as measured in scalp hair (HairGC), are associated with obesity and the metabolic syndrome (MetS). It is not known whether this represents a state of obesity or whether chronic hypercortisolism may influence the course or reversibility of obesity. In this study we longitudinally examine the relation between HairGC concentrations and metabolic syndrome parameters in patients with obesity who participate in a 1.5 year i...